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Molecular Insights into Transgenerational Non-Genetic Inheritance of Acquired Behaviours

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Title

Molecular Insights into Transgenerational Non-Genetic Inheritance of Acquired Behaviours

Subject

Genetics

Electronic Resource Item Type Metadata

Author(s)

Isabelle M Mansuy, Johannes Bohacek

Journal Name

Nature Reviews Genetics

Volume

Vol. 16

Issue

No. 11

Publication Date

2015

Publisher

Nature Publishing Group

Document Type

Journal article

Language

English

Access

Restricted Access

Abstract

Behavioural traits in mammals are influenced by environmental factors, which can interact with the genome and modulate its activity by complex molecular interplay. Environmental experiences can modify social, emotional and cognitive behaviours during an individual’s lifetime, and result in acquired behavioural traits that can be transmitted to subsequent generations. This Review discusses the concept of, and experimental support for, non-genetic transgenerational inheritance of acquired traits involving the germ line in mammals. Possible mechanisms of induction and maintenance during development and adulthood are considered along with an interpretation of recent findings showing the involvement of epigenetic modifications and non-coding RNAs in male germ cells.

Cataloger

Kristen Walker

Citation

“Molecular Insights into Transgenerational Non-Genetic Inheritance of Acquired Behaviours,” ICMGLT Digital Library, accessed November 3, 2026, https://library.icmglt.org/items/show/912.

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