https://library.icmglt.org/files/original/0116704610cea6243124a4291ba33f8e.pdf 989a297f14b1c2b34ce392345972f728 Electronic Resource View Source <a href="https://doi.org/10.3389/fnbeh.2019.00113">https://doi.org/10.3389/fnbeh.2019.00113</a> Document Type Journal article Author(s) Audrey Fontaine, Jacqueline Blundell, James Drover, Phillip E MacCallum, Sriya Bhattacharya Volume Vol. 13 Publisher PubMed Central Journal Name Frontiers in Behavioral Neuroscience Publication Date 2019 Language English Access Open Access Abstract Although most humans will experience some type of traumatic event in their lifetime only a small set of individuals will go on to develop post-traumatic stress disorder (PTSD). Differences in sex, age, trauma type, and comorbidity, along with many other elements, contribute to the heterogenous manifestation of this disorder. Nonetheless, aberrant hypothalamus-pituitary-adrenal (HPA) axis activity, especially in terms of cortisol and glucocorticoid receptor (GR) alterations, has been postulated as a tenable factor in the etiology and pathophysiology of PTSD. Moreover, emerging data suggests that the harmful effects of traumatic stress to the HPA axis in PTSD can also propagate into future generations, making offspring more prone to psychopathologies. Predator stress models provide an ethical and ethologically relevant way to investigate tentative mechanisms that are thought to underlie this phenomenon. In this review article, we discuss findings from human and laboratory predator stress studies that suggest changes to DNA methylation germane to GRs may underlie the generational effects of trauma transmission. Understanding mechanisms that promote stress-induced psychopathology will represent a major advance in the field and may lead to novel treatments for such devastating, and often treatment-resistant trauma and stress-disorders. Cataloger Kristen Walker Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models Subject The topic of the resource Neurosciences Intergenerational Transmission of Trauma Post-Traumatic Stress Disorder (PTSD) Stress