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              <text>&lt;a href="https://doi.org/10.1016/j.jand.2024.11.014"&gt;https://doi.org/10.1016/j.jand.2024.11.014&lt;/a&gt;</text>
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              <text>Lu Wang, Euridice Martínez Steele, Mengxi Du, Hanqi Luo, Xuehong Zhang, Dariush Mozaffarian, Fang Fang Zhang</text>
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              <text>Vol. 125</text>
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              <text>No. 7</text>
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              <text>Elsevier, for the Academy of Nutrition and Dietetics</text>
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              <text>Journal of the Academy of Nutrition and Dietetics</text>
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              <text>2025</text>
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              <text>22122680</text>
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              <text>English</text>
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          <name>Abstract</name>
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              <text>Background&#13;
Intake of ultra-processed foods (UPF) provides more than half of the daily energy US adults consume. Still, the prospective association of UPF consumption with mortality in the general US population remains understudied.&#13;
Objective&#13;
To investigate the prospective association of UPF consumption with mortality in a nationally representative sample of US adults.&#13;
Design&#13;
A prospective cohort analysis was conducted by linking baseline measurement from the National Health and Nutrition Examination Survey with mortality information from the National Death Index. The percentage of total energy consumed from UPF, defined by the Nova classification system, was computed based on dietary data collected using 24-hour diet recalls.&#13;
Participants/setting&#13;
This study included 38 148 nationally representative US adults aged 20 years and older who participated in National Health and Nutrition Examination Survey between 2003-2004 and 2017-2018 and provided dietary intake data, with linkage to mortality data.&#13;
Main outcome measures&#13;
Information on all-cause and cause-specific mortality was obtained from linkage to the National Death Index through December 31, 2019.&#13;
Statistical analysis performed&#13;
Cox proportional hazard models estimated the multivariable-adjusted hazard ratios and 95% CIs for the association between UPF intake and mortality.&#13;
Results&#13;
During a median follow-up of 8.0 years, 4611 deaths were confirmed, including 2064 deaths from cardiometabolic disorders and 1046 deaths from cancer. After multivariable adjustments, each 10-point increment in usual percentage of total energy from UPF was associated with a 9% higher risk of all-cause mortality (hazard ratio 1.09, 95% CI 1.04 to 1.14). The association remained significant after adjusting for the overall diet quality measured by the Health Eating Index 2015 (hazard ratio 1.06, 95% CI 1.00 to 1.11; P &lt; .05). Among subgroups, sugar-sweetened beverages, ready-to-eat or -heat mixed dishes, ultra-processed dairy products, and ultra-processed oil/fat, condiments, and sauces were associated with an increased risk of all-cause or cause-specific mortality. Ultra-processed vegetables and legumes were associated with a reduced risk.&#13;
Conclusions&#13;
In this nationally representative study of US adults, higher consumption of UPF was associated with a higher risk of all-cause mortality, and this association was not fully explained by overall diet quality.</text>
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              <text>Haley Lesemann</text>
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                <text>Association Between Ultra-processed Food Consumption and Mortality Among US Adults: Prospective Cohort Study of the National Health and Nutrition Examination Survey, 2003-2018</text>
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                <text>Processed foods--Health aspects--United States</text>
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              <text>&lt;a href="https://doi.org/10.1093/ageing/afae268"&gt;https://doi.org/10.1093/ageing/afae268&lt;/a&gt;</text>
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              <text>Barbara Rita Cardoso⁠, Junxiu Liu, Priscila Machado, Dayoon Kwon, Daniel W Belsky, Euridice Martinez Steele</text>
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              <text>Vol. 53</text>
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              <text>No. 12</text>
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              <text>Oxford University Press (Oxford)</text>
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              <text>Age and Ageing</text>
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              <text>2024</text>
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              <text>14682834</text>
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              <text>United States</text>
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            <elementText elementTextId="9853">
              <text>English</text>
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          <name>Abstract</name>
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              <text>Background&#13;
The association between ultra-processed food (UPF) intake and markers of biological ageing has been scarcely investigated, despite the evident adverse health effects associated with UPF. This study aimed to test the association between UPF intake and biological ageing, and evaluate how much of this association is accounted for by overall diet quality.&#13;
&#13;
Methods&#13;
This cross-sectional study assessed 16 055 participants aged 20–79 years (51% women, 46 ± 0.3 years) from the National Health and Nutrition Examination Survey (NHANES) 2003–2010. Dietary UPF intake was assessed using the Nova system. Values were expressed as % of total energy intake and were denominated as a continuous variable and in quintiles. Diet quality was assessed with the American Heart Association 2020 and the Healthy Eating Index 2015. Biological ageing was assessed using the PhenoAge algorithm.&#13;
&#13;
Results&#13;
For each 10% of energy intake accounted for by UPF, participants were 0.21 (95%CI 0.16–0.26) years biologically older in terms of PhenoAge. As compared to participants in the lowest UPF quintile (≤39%), those in the highest UPF quintile (68–100%) were 0.86 (95% CI 0.55, 1.16) years older (P-for-trend across quintiles ≤0.001). Adherence to a healthy diet moderately attenuated the relationship between UPF and PhenoAge (adjusted β = 0.14 per 10% increment of UPF).&#13;
&#13;
Conclusions&#13;
Adults with higher UPF tended to be biologically older. This association is partly independent of diet quality, suggesting that food processing may contribute to biological ageing acceleration. Our findings point to a compelling reason to target UPF consumption to promote healthier ageing.</text>
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          <elementTextContainer>
            <elementText elementTextId="9856">
              <text>Haley Lesemann</text>
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            <description>A name given to the resource</description>
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                <text>Association Between Ultra-processed Food Intake and Biological Ageing in US Adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003–2010</text>
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            <description>The topic of the resource</description>
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                <text>Processed foods--Health aspects--United States</text>
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              <text>&lt;a href="https://doi.org/10.1016/j.amepre.2025.108250"&gt;https://doi.org/10.1016/j.amepre.2025.108250&lt;/a&gt;</text>
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              <text>Maria Alvim Leite, Leandro F.M. Rezende, Eurídice Martínez-Steele, Edward Giovannucci, Xuehong Zhang, Renata Bertazzi Levy</text>
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              <text>Vol. 71</text>
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              <text>No. 1</text>
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              <text>Elsevier, for the American Journal of Preventive Medicine</text>
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              <text>American Journal of Preventive Medicine</text>
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              <text>2026</text>
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              <text>07493797</text>
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              <text>Brazil</text>
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            <elementText elementTextId="9870">
              <text>English</text>
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              <text>Introduction&#13;
Ultraprocessed dietary patterns have been associated with higher risk of weight gain. Previous studies were conducted in high-income countries using dietary assessment tools not specifically designed to identify ultraprocessed foods. The purpose of this study was to examine the prospective association between ultraprocessed dietary pattern and risk of weight gain in Brazilian adults.&#13;
Methods&#13;
Data from 24,453 participants from NutriNet-Brasil cohort study who responded to 2 Nova24h dietary recalls at baseline and were followed for a median of 43.6 months were analyzed. Ultraprocessed dietary pattern was assessed on the basis of the contribution of ultraprocessed foods to total energy intake. Weight gain was defined as ≥5% and ≥10% increase from baseline body weight on the basis of self-reported measurements. Cox proportional hazards models, and stratified analyses were performed.&#13;
Results&#13;
A linear dose–response association was observed: for each 10% increase in ultraprocessed foods contribution, the risk of ≥5% weight gain increased by 5% (10,092 cases, hazard ratio=1.05; 95% CI=1.04, 1.07), and the risk of ≥10% weight gain increased by 8% (4,865 cases, hazard ratio=1.08; 95% CI=1.06, 1.10). Compared with participants in the lowest quintile (&lt;11.8% of ultraprocessed foods), those in the highest quintile (≥34.0%) had higher risk of weight gain (≥5%: hazard ratio=1.23; 95% CI=1.15, 1.31; ≥10%: hazard ratio=1.35; 95% CI=1.23, 1.48). These associations persisted but attenuated after adjustment for diet nutritional profile.&#13;
Conclusions&#13;
Higher exposure to ultraprocessed dietary pattern was associated with an increased risk of weight gain in Brazilian adults.</text>
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              <text>Haley Lesemann</text>
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                <text>Association Between Ultraprocessed Dietary Pattern and Weight Gain in Adults: The Nutrinet-Brasil Cohort Study</text>
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                <text>Processed foods--Health aspects--Brazil</text>
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              <text>&lt;a href="https://doi.org/10.1007/s00394-025-03740-8"&gt;https://doi.org/10.1007/s00394-025-03740-8&lt;/a&gt;</text>
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              <text>Mathuramat Seesen, Kiara Chang, Jennie C. Parnham, Anthony A. Laverty, Christopher Millett, Fernanda Rauber, Renata B. Levy, Martin White, Edward W. Gregg, Eszter P. Vamos </text>
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              <text>Purpose&#13;
Little is known about the association between low- and no-calorie sweetened (LCS) product consumption and children’s dietary quality, despite the promotion of these products as sugar alternatives. This study examines the trends and associations between LCS product consumption and intakes of free sugar, ultra-processed food and beverages (UPFB), and other key dietary components among UK children.&#13;
&#13;
Methods&#13;
Repeated annual cross-sectional data from the National Diet and Nutrition Survey (2008/09-2018/19) for children aged 4–18 years (N = 5,922) were analysed. Children were categorized into No-LCS (0%g/day), Low-LCS (≤ 6.8%g/day), Mid-LCS (6.9–17.4%g/day), and High-LCS (≥ 17.4%g/day) groups based on a four-day food diary. The trends and associations were assessed using multivariable linear regression models, adjusted for sociodemographic factors.&#13;
&#13;
Results&#13;
In 2008/09, the High-LCS group had lower free sugar intake (-1.9%kcaltotal/day; 95% CI: -2.8, -1.0) compared with the No-LCS group. Over 11 years, free sugar intake declined in all groups, with similar declines observed across the LCS groups. By 2018/19, no difference in free sugar intake was observed between the High-LCS and No-LCS groups. Moreover, consumption of UPFB decreased (-0.8%gtotal/day per year; 95%CI: -1.1, -0.6) while water increased (2.7%gdrink/day per year; 95%CI: 2.2, 3.1) in the No-LCS group over 11 years. Similar changes were observed in other LCS groups but were less pronounced in the High-LCS (vs. No-LCS) group.&#13;
&#13;
Conclusions&#13;
LCS product consumption was not consistently associated with lower free sugar intake among UK children. Differences in intakes of ultra-processed foods and water highlight the importance of considering dietary patterns beyond individual nutrients.</text>
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              <text>Many epidemiological studies have shown an association between infectious agents, particularly viruses, and psychiatric disorders including schizophrenia. However, evidence of a viral infection in the brain that associates with schizophrenia (SCZ), bipolar disorder (BPD), and major depression (MDD) has not been found. A potential reason for this discrepancy may be that viruses are more likely to infect the neuroepithelium than neural tissue. To test this hypothesis, we used viral sequence enrichment technology and performed RNA sequencing in postmortem choroid plexus (CP) isolated from 84 SCZ, 73 BPD, 23 MDD cases and 76 unaffected controls (CNT) from the Stanley Medical Research Institute brain collection. This approach enabled us to identify the presence of 13 viral species in the CP of 46 subjects. We discovered that CP samples collected from subjects with SCZ and BPD are more likely to contain viral sequences. In terms of individual viruses, the Hepatitis C Virus (HCV) was the only viral species that reached the threshold of statistical significance for an association with SCZ and BPD. Therefore, we focused on HCV to characterize the association between psychiatric disorders and viruses. Analysis of the TriNetX electronic health record database with data on 285 million patients revealed that the prevalence of chronic HCV was 3.6 and 3.9 percent in the SCZ and BPD populations respectively. The prevalence of chronic HCV in these populations was almost double that observed for MDD (1.8%) and approximately 7-fold higher than the control population (0.5%). These findings confirm previous studies that report higher HCV prevalence in SCZ and BPD and suggest that HCV infection may be associated with disease pathology rather than behaviors such as intravenous drug injection, since these behaviors are present in all three disorders. We analyzed hippocampus RNA sequencing data from the subjects identified to be HCV positive via sequence capture. We found that although the virus was absent in this tissue, HCV RNA in the CP was associated with consistent host transcriptional changes in the hippocampus that were potentially related to the innate immune response. Our results are consistent with previous studies and provide clues regarding the contribution of viruses to the pathology of psychiatric disorders.</text>
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                <text>Association of Viral RNAs in the Choroid Plexus with Bipolar Disorder and Schizophrenia and Evidence for the Hepatitis C Virus Involvement in Neuropathology</text>
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              <text>Divyangana Rakesh, Ekaterina Sadikova, Katie A. McLaughlin </text>
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              <text>Lower parental socioeconomic status (SES) is consistently linked to lower academic achievement among adolescents, with early disparities persisting into adulthood. However, the neurobiological mechanisms underlying these associations are not well understood. This preregistered study investigates the associations between household and neighborhood disadvantage—measured by income-to-needs ratio, parental educational attainment, and neighborhood SES—changes in within-network functional connectivity, and school grades, using longitudinal data from the Adolescent Brain Cognitive Development Study (N = 4745; age at baseline = 119.1 ± 7.5 months; age at 2-year follow up = 143.6 ± 7.8 months; age at 3-year follow up = 154.8 ± 7.7 months). Within-network connectivity changed significantly from baseline to follow-up, increasing in most networks (e.g., default mode, fronto-parietal) and decreasing in a few (e.g., salience, ventral attention). After controlling for other SES indicators, parental education and neighborhood disadvantage, but not income, were associated with changes in connectivity across several brain networks, including reduced increases in default mode, cingulo-opercular, and visual network connectivity and greater increases in within-sensorimotor network connectivity. Further, changes in sensorimotor connectivity mediated the relationship between parental educational attainment and academic achievement three years later. These findings highlight the importance of parental education and neighborhood environments in shaping neurodevelopmental trajectories that influence academic outcomes. Understanding the mechanisms that link socioeconomic disadvantage with academic outcomes could inform interventions aimed at reducing persistent achievement gaps.&#13;
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              <text>Guangzhou, Guangdong Province, China</text>
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              <text>The association between NOVA-classified food processing level and colorectal cancer (CRC) prognosis remains unclear, particularly regarding the potential mediating role of inflammation. We included 2799 patients from Guangdong Colorectal Cancer Cohort. Dietary intake was assessed using a validated food frequency questionnaire, with intakes quantified in g day−1 and classified according to the NOVA system. Six inflammatory biomarkers (C-reactive protein and five hematological indices) were evaluated. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), CRC-specific survival (CSS), and recurrence- or metastasis-free survival (RMFS). Isocaloric substitution models tested replacing 25 g of ultra-processed foods (UPF) or processed foods (NOVA 3) with unprocessed/minimally processed foods (NOVA 1). Mediation analyses quantified the contribution of inflammation and stratified analyses examined effect modification by sex, age and cancer site. Over a median follow-up of 77.63 months, 715 deaths (647 CRC-specific) and 557 instances of recurrence/metastasis occurred. Higher NOVA 1 consumption was associated with improved OS (HRQ4 vs. Q1: 0.73, 95% CI: 0.56, 0.96) and CSS (HRQ4 vs. Q1, 0.72, 95% CI: 0.54, 0.96), particularly in rectal cancer patients (P-interaction &lt; 0.05). Replacing UPFs with NOVA 1 improved OS (HR: 0.992, 95% CI 0.984, 0.999) and CSS (HR: 0.990, 95% CI 0.982, 0.998), with similar associations for NOVA 3. Inflammation mediated 5.58–9.40% of these associations. Collectively, higher NOVA 1 consumption was associated with improved OS and CSS among CRC patients, partly through reduced systemic inflammation. Substituting UPFs or NOVA 3 with NOVA 1 may confer additional survival benefits.&#13;
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              <text>Objective. Low  socioeconomic  status  (SES)  during  childhood  is  associated  with  higher  levels  of  youth psychopathology.  However, limited longitudinal  work has examinedthe  role  of both  household  and neighborhood SES  in  shaping  mental  health  trajectories over  timeusing large population-based  data.The goal  of  the  present  study  was  to  characterize associations  between  SES andchanges  in  mental  health problems during early adolescence.Methods. Weinvestigatedindependent and jointassociations of householdincome-to-needsratio, parent educational attainment, material hardship,andneighborhood disadvantagewith internalizing, externalizing, and   attention symptom   trajectoriesusing   longitudinal   data   from   the   Adolescent   Brain   Cognitive Development Study. Youth-reported  mental  health was assessed across six time-points  from age 10 to  13 years(M=10.4, SD=0.63years at T1,N=9,488) and SES was assessed six months prior to T1.Results.Main effectsindicated that high SES was associated with lower mental health symptoms. However, longitudinally, higherSESwas  associated  with  greater  increases  in  mental  health  problemsover  time. A higher income-to-needs  ratio  predicted  greater  increases  in  internalizing,  externalizing,and attention problems.Two-way  interactions  between  SES  indicators  predicting  changes  in  symptoms  were  non-significant.Conclusion.Our findingthat youth from higher-SES backgrounds exhibited greater increases in mental health problems during early adolescence contrasts with findings from prior cross-sectional studies. However, mental health problems are on the rise and the landscape of risk for psychopathologyis changing. More research is needed to understand howchildhood SES contributes torisk and resilience for psychopathologyduring the transition to adolescence.</text>
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              <text>Black and Latinx youth experience earlier pubertal timing relative to their non-stigmatized peers. Research on determinants of this increased risk has largely focused on aspects of individuals (e.g., body mass index) or their proximal environment (e.g., socioeconomic status), to the exclusion of broader macro-social factors. Using 2 years of Adolescent Brain Cognitive Development Study® data, we examined whether structural stigma (e.g., state-level policies, aggregated prejudicial attitudes) was associated with hormonal and physical markers of pubertal development. Baseline results documented earlier pubertal timing among Black girls (hormones) and Latinx girls and boys (youth and/or caregiver report) in states with higher (vs. lower) levels of structural racism and xenophobia, respectively. Observed associations were comparable in effect size to a well-established correlate of pubertal development, body mass index, and remained 1 year later among these stigmatized (vs. non-stigmatized) groups. Findings suggest the need to broaden the study of determinants of pubertal development to include macro-social factors.&#13;
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              <text>Testosterone has been theorized to influence the development of post-traumatic stress disorder (PTSD). However, the relationship between testosterone level and PTSD is still not well understood. We evaluated the potential association between testosterone and subsequent development of PTSD symptoms using a large sample size, in a civilian context, inclusive of both males and females. Out of around 500,000 total UK Biobank participants, our sample had 130,471 participants who: had testosterone measures, completed the mental health questionnaire, and passed outlier exclusion. After adjusting for relevant covariates, we used linear regression to assess the relationship between testosterone level and future development of symptoms, in males and females separately (Nmales = 61,758, Nfemales = 67,053). In both males and females, small but significant nonlinear (and oftentimes U-shaped) relationships were observed between testosterone levels and PTSD symptoms. When grouping participants into deciles of testosterone for both sexes, the strongest associations between testosterone levels and PTSD symptoms were observed in the central deciles. For example, for total testosterone, compared to decile 1: individuals in decile 7 had the lowest PTSD symptom scores in both males (beta = −0.16, p = 1.58 × 10−3) and females (beta = −0.23, p = 3.04 × 10−5). We also found that body mass index (BMI) moderated the relationship between testosterone and PTSD symptoms, such that the relationship was considerably stronger among individuals with higher BMI. Results were similar for depression and anxiety measures. Analyses using calculated free testosterone (cFT) and the free androgen index (FAI) were generally consistent with total testosterone (TT) results. These findings suggest that mid-range testosterone levels are associated with the lowest risk of PTSD symptoms in both sexes, and future work should seek to examine if this relationship is causal.</text>
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              <text>Given the disproportionate impact of COVID-19, it is important to understand factors that may underlie Black American emerging adults’ adherence to safety guidelines that could potentially reduce spread of illness and hospitalization. The current study examined how COVID-19 worry about mental health (CWMH) and COVID-19 worry about physical health (CWPH) predicted use of face masks, and whether perceived discrimination moderated these relations. The sample included 164 Black American emerging adults, age 18–25 (M = 8.82, SD = 2.06). Findings indicated that perceived discrimination was a moderator, such that at higher levels of discrimination, CWMH predicted use of face masks, but this relation was not significant at lower levels of discrimination. CWPH did not predict use of face masks, and perceived discrimination was not a moderator of this relation. Overall, considering the role of race-related experiences and CWMH is important for understanding the use of face masks among Black Americans.</text>
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              <text>Since the inception of attachment theory, parent-child relationships has been examined in different populations, including autistic children. Attachment in autistic children has been measured using inconsistent separation-reunion procedures, making it difficult to examine whether autistic children are more or less likely to develop a secure attachment compared to non-autistic children. This study aims to meta-analyze data from studies that have assessed attachment in autistic children using a standardized version of the Strange Situation Procedure. Using the CASCADE catalogue, we identified six studies (n = 202). Results revealed that 45.6% were classified as secure, 18.7% as avoidant, 8.5% as resistant, and 27.2% as disorganized, which was statistically similar to the proportions of attachment categories in general population. Moderator analyses revealed a higher proportion of secure attachment among older children and more recently published studies. Future research should focus on unifying methodological approaches to studying attachment in autistic children.</text>
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