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              <text>&lt;a href="https://doi.org/10.1038/s41398-025-03387-3"&gt;https://doi.org/10.1038/s41398-025-03387-3&lt;/a&gt;</text>
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              <text>Maree J. Webster, Ashwin Balagopal, Jeffrey Quinn, Ou Chen, Sarven Sabunciyan </text>
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              <text>Translational Psychiatry</text>
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              <text>Many epidemiological studies have shown an association between infectious agents, particularly viruses, and psychiatric disorders including schizophrenia. However, evidence of a viral infection in the brain that associates with schizophrenia (SCZ), bipolar disorder (BPD), and major depression (MDD) has not been found. A potential reason for this discrepancy may be that viruses are more likely to infect the neuroepithelium than neural tissue. To test this hypothesis, we used viral sequence enrichment technology and performed RNA sequencing in postmortem choroid plexus (CP) isolated from 84 SCZ, 73 BPD, 23 MDD cases and 76 unaffected controls (CNT) from the Stanley Medical Research Institute brain collection. This approach enabled us to identify the presence of 13 viral species in the CP of 46 subjects. We discovered that CP samples collected from subjects with SCZ and BPD are more likely to contain viral sequences. In terms of individual viruses, the Hepatitis C Virus (HCV) was the only viral species that reached the threshold of statistical significance for an association with SCZ and BPD. Therefore, we focused on HCV to characterize the association between psychiatric disorders and viruses. Analysis of the TriNetX electronic health record database with data on 285 million patients revealed that the prevalence of chronic HCV was 3.6 and 3.9 percent in the SCZ and BPD populations respectively. The prevalence of chronic HCV in these populations was almost double that observed for MDD (1.8%) and approximately 7-fold higher than the control population (0.5%). These findings confirm previous studies that report higher HCV prevalence in SCZ and BPD and suggest that HCV infection may be associated with disease pathology rather than behaviors such as intravenous drug injection, since these behaviors are present in all three disorders. We analyzed hippocampus RNA sequencing data from the subjects identified to be HCV positive via sequence capture. We found that although the virus was absent in this tissue, HCV RNA in the CP was associated with consistent host transcriptional changes in the hippocampus that were potentially related to the innate immune response. Our results are consistent with previous studies and provide clues regarding the contribution of viruses to the pathology of psychiatric disorders.</text>
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                <text>Association of Viral RNAs in the Choroid Plexus with Bipolar Disorder and Schizophrenia and Evidence for the Hepatitis C Virus Involvement in Neuropathology</text>
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              <text>Divyangana Rakesh, Ekaterina Sadikova, Katie A. McLaughlin </text>
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              <text>Lower parental socioeconomic status (SES) is consistently linked to lower academic achievement among adolescents, with early disparities persisting into adulthood. However, the neurobiological mechanisms underlying these associations are not well understood. This preregistered study investigates the associations between household and neighborhood disadvantage—measured by income-to-needs ratio, parental educational attainment, and neighborhood SES—changes in within-network functional connectivity, and school grades, using longitudinal data from the Adolescent Brain Cognitive Development Study (N = 4745; age at baseline = 119.1 ± 7.5 months; age at 2-year follow up = 143.6 ± 7.8 months; age at 3-year follow up = 154.8 ± 7.7 months). Within-network connectivity changed significantly from baseline to follow-up, increasing in most networks (e.g., default mode, fronto-parietal) and decreasing in a few (e.g., salience, ventral attention). After controlling for other SES indicators, parental education and neighborhood disadvantage, but not income, were associated with changes in connectivity across several brain networks, including reduced increases in default mode, cingulo-opercular, and visual network connectivity and greater increases in within-sensorimotor network connectivity. Further, changes in sensorimotor connectivity mediated the relationship between parental educational attainment and academic achievement three years later. These findings highlight the importance of parental education and neighborhood environments in shaping neurodevelopmental trajectories that influence academic outcomes. Understanding the mechanisms that link socioeconomic disadvantage with academic outcomes could inform interventions aimed at reducing persistent achievement gaps.&#13;
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              <text>The association between NOVA-classified food processing level and colorectal cancer (CRC) prognosis remains unclear, particularly regarding the potential mediating role of inflammation. We included 2799 patients from Guangdong Colorectal Cancer Cohort. Dietary intake was assessed using a validated food frequency questionnaire, with intakes quantified in g day−1 and classified according to the NOVA system. Six inflammatory biomarkers (C-reactive protein and five hematological indices) were evaluated. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), CRC-specific survival (CSS), and recurrence- or metastasis-free survival (RMFS). Isocaloric substitution models tested replacing 25 g of ultra-processed foods (UPF) or processed foods (NOVA 3) with unprocessed/minimally processed foods (NOVA 1). Mediation analyses quantified the contribution of inflammation and stratified analyses examined effect modification by sex, age and cancer site. Over a median follow-up of 77.63 months, 715 deaths (647 CRC-specific) and 557 instances of recurrence/metastasis occurred. Higher NOVA 1 consumption was associated with improved OS (HRQ4 vs. Q1: 0.73, 95% CI: 0.56, 0.96) and CSS (HRQ4 vs. Q1, 0.72, 95% CI: 0.54, 0.96), particularly in rectal cancer patients (P-interaction &lt; 0.05). Replacing UPFs with NOVA 1 improved OS (HR: 0.992, 95% CI 0.984, 0.999) and CSS (HR: 0.990, 95% CI 0.982, 0.998), with similar associations for NOVA 3. Inflammation mediated 5.58–9.40% of these associations. Collectively, higher NOVA 1 consumption was associated with improved OS and CSS among CRC patients, partly through reduced systemic inflammation. Substituting UPFs or NOVA 3 with NOVA 1 may confer additional survival benefits.&#13;
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              <text>Objective. Low  socioeconomic  status  (SES)  during  childhood  is  associated  with  higher  levels  of  youth psychopathology.  However, limited longitudinal  work has examinedthe  role  of both  household  and neighborhood SES  in  shaping  mental  health  trajectories over  timeusing large population-based  data.The goal  of  the  present  study  was  to  characterize associations  between  SES andchanges  in  mental  health problems during early adolescence.Methods. Weinvestigatedindependent and jointassociations of householdincome-to-needsratio, parent educational attainment, material hardship,andneighborhood disadvantagewith internalizing, externalizing, and   attention symptom   trajectoriesusing   longitudinal   data   from   the   Adolescent   Brain   Cognitive Development Study. Youth-reported  mental  health was assessed across six time-points  from age 10 to  13 years(M=10.4, SD=0.63years at T1,N=9,488) and SES was assessed six months prior to T1.Results.Main effectsindicated that high SES was associated with lower mental health symptoms. However, longitudinally, higherSESwas  associated  with  greater  increases  in  mental  health  problemsover  time. A higher income-to-needs  ratio  predicted  greater  increases  in  internalizing,  externalizing,and attention problems.Two-way  interactions  between  SES  indicators  predicting  changes  in  symptoms  were  non-significant.Conclusion.Our findingthat youth from higher-SES backgrounds exhibited greater increases in mental health problems during early adolescence contrasts with findings from prior cross-sectional studies. However, mental health problems are on the rise and the landscape of risk for psychopathologyis changing. More research is needed to understand howchildhood SES contributes torisk and resilience for psychopathologyduring the transition to adolescence.</text>
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              <text>Haley Lesemann</text>
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              <text>Rachel M. Martino, Nathan L. Hollinsaid, Natalie L. Colich, Katie A. McLaughlin, Mark L. Hatzenbuehler </text>
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              <text>Black and Latinx youth experience earlier pubertal timing relative to their non-stigmatized peers. Research on determinants of this increased risk has largely focused on aspects of individuals (e.g., body mass index) or their proximal environment (e.g., socioeconomic status), to the exclusion of broader macro-social factors. Using 2 years of Adolescent Brain Cognitive Development Study® data, we examined whether structural stigma (e.g., state-level policies, aggregated prejudicial attitudes) was associated with hormonal and physical markers of pubertal development. Baseline results documented earlier pubertal timing among Black girls (hormones) and Latinx girls and boys (youth and/or caregiver report) in states with higher (vs. lower) levels of structural racism and xenophobia, respectively. Observed associations were comparable in effect size to a well-established correlate of pubertal development, body mass index, and remained 1 year later among these stigmatized (vs. non-stigmatized) groups. Findings suggest the need to broaden the study of determinants of pubertal development to include macro-social factors.&#13;
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              <text>Testosterone has been theorized to influence the development of post-traumatic stress disorder (PTSD). However, the relationship between testosterone level and PTSD is still not well understood. We evaluated the potential association between testosterone and subsequent development of PTSD symptoms using a large sample size, in a civilian context, inclusive of both males and females. Out of around 500,000 total UK Biobank participants, our sample had 130,471 participants who: had testosterone measures, completed the mental health questionnaire, and passed outlier exclusion. After adjusting for relevant covariates, we used linear regression to assess the relationship between testosterone level and future development of symptoms, in males and females separately (Nmales = 61,758, Nfemales = 67,053). In both males and females, small but significant nonlinear (and oftentimes U-shaped) relationships were observed between testosterone levels and PTSD symptoms. When grouping participants into deciles of testosterone for both sexes, the strongest associations between testosterone levels and PTSD symptoms were observed in the central deciles. For example, for total testosterone, compared to decile 1: individuals in decile 7 had the lowest PTSD symptom scores in both males (beta = −0.16, p = 1.58 × 10−3) and females (beta = −0.23, p = 3.04 × 10−5). We also found that body mass index (BMI) moderated the relationship between testosterone and PTSD symptoms, such that the relationship was considerably stronger among individuals with higher BMI. Results were similar for depression and anxiety measures. Analyses using calculated free testosterone (cFT) and the free androgen index (FAI) were generally consistent with total testosterone (TT) results. These findings suggest that mid-range testosterone levels are associated with the lowest risk of PTSD symptoms in both sexes, and future work should seek to examine if this relationship is causal.</text>
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              <text>Objectives: Native Americans have higher rates of mental health symptoms and chronic disease compared to the general population, partly due to historical loss (eg, land, language, culture). Few studies have examined strength-based characteristics that enable Native populations to cope with loss and reduce loss-related emotional symptoms (eg, anxiety, anger). Methods: We recruited 81 participants (mean age 47.9 years; 61% female) in a midwestern Anishinaabe community using convenience sampling. Participants completed questionnaires assessing historical loss, loss-related emotional symptoms, psychological resilience, and maladaptive and adaptive coping strategies. Hierarchical regression analyses examined associations of historical loss, psychological resilience, and coping strategies with loss-related emotional symptoms after controlling for demographics. Results: Historical loss ( β = .56, p &lt; .001) and maladaptive coping strategies ( β = .23, p &lt; .05) were positively associated with loss-related symptoms among Anishinaabe community members; psychological resilience was inversely associated with loss-related symptoms ( β = -.21, p &lt; .05). Adaptive coping strategies ( β = .02, p &gt; .05) were not associated with loss-related symptoms. Conclusions: Findings suggest that historical loss is associated with loss-related emotional symptoms in the Anishinaabe population. Public health programs that foster psychological resilience and reduce maladaptive coping strategies are needed to address these loss-related symptoms. </text>
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              <text>Since the inception of attachment theory, parent-child relationships has been examined in different populations, including autistic children. Attachment in autistic children has been measured using inconsistent separation-reunion procedures, making it difficult to examine whether autistic children are more or less likely to develop a secure attachment compared to non-autistic children. This study aims to meta-analyze data from studies that have assessed attachment in autistic children using a standardized version of the Strange Situation Procedure. Using the CASCADE catalogue, we identified six studies (n = 202). Results revealed that 45.6% were classified as secure, 18.7% as avoidant, 8.5% as resistant, and 27.2% as disorganized, which was statistically similar to the proportions of attachment categories in general population. Moderator analyses revealed a higher proportion of secure attachment among older children and more recently published studies. Future research should focus on unifying methodological approaches to studying attachment in autistic children.</text>
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              <text>Identifying brain mechanisms implicated in the intergenerational transmission of major depressive disorder (MDD) is crucial for early detection and developing novel interventions. One promising mechanism involves altered intrinsic connectivity patterns in brain networks supporting emotion processing, including within the cognitive control network (CCN). The current preliminary study used resting state functional magnetic resonance imaging (fMRI) to examine whether altered CCN connectivity patterns are a brain-based mechanism of intergenerational risk for depression. We tested whether CCN connectivity patterns (1) differentiated mothers with and without recurrent MDD, (2) differentiated their high-risk (HR) and low-risk (LR) daughters, and (3) served as prospective predictors of daughters’ depressive symptoms over a multi-wave follow-up. Participants were 56 mother–daughter pairs who completed a resting state fMRI scan. Mothers with, versus without, a history of MDD exhibited reduced connectivity between the CCN and other regions within the CCN, such as the middle frontal gyrus and dorsal anterior cingulate cortex (ACC). Reduced connectivity between the CCN and dorsal ACC was also observed in HR, relative to LR, daughters, correlated significantly among mothers and daughters, and associated with higher depression symptoms in daughters across 18 months. Reduced connectivity within the CCN may constitute one brain-based marker to further investigate as a target for prevention to attenuate the intergenerational transmission of depression.&#13;
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              <text>Objective: Culture may influence attitudes toward alcohol intervention strategies among American Indian/Alaska Native (AI/AN) individuals. This study examined AI/AN college students’ attitudes regarding harm-reduction (HR) and abstinence-only (AO) intervention strategies to overcome problems with alcohol, including perceived social support for using these strategies. Method: Participants were AI/AN college students who consumed alcohol (N = 159) and completed a single in-person data collection session. Separate analyses of covariance were conducted to examine perceived effectiveness and self-efficacy for the intervention strategies and perceived support of friends and family. Results: No difference in perceived effectiveness was found, while self-efficacy was higher for HR than AO for both hazardously and nonhazardously drinking groups. Likewise, participants perceived greater social support for HR than AO strategies, even from friends or family who are abstinent, and no differences were found between hazardous and nonhazardous drinking groups in perceived support for these interventions. Conclusions: AI/AN students who drink perceived no difference in effectiveness between HR and AO strategies and were more confident in their abilities to utilize HR strategies over AO. Regardless of drinking status, participants perceived they would have greater social support for HR compared with AO strategies from friends and family. The findings indicate that HR intervention strategies may be a socially valid intervention option for AI/AN college students. (PsycInfo Database Record (c) 2026 APA, all rights reserved)</text>
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              <text>&lt;a href="https://doi.org/10.1155/hsc/2650302"&gt;https://doi.org/10.1155/hsc/2650302&lt;/a&gt;</text>
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              <text>Genevieve A. Dingle, Christina Aggar, Nikita Arslanovski, Thomas Astell-Burt, J. R. Baker, Ruthanne Baxter, Michelle Bissett, Mhairi Bowe, Eric Brymer, Alexandra Burton, Richard Byng, Julian Elston, Daisy Fancourt, Xiaoqi Feng, Emmanuel Fino, Rosanne Freak-Poli, Lydia Harkin, Daniel Hayes, Emma Hazeldine, Blerina Kellezi, Niamh McNamara, Leah Sharman, Clifford Stevenson, Juliet Wakefield, Katey Warran, Leanne Wells, Laura Wright, Yvonne Zurynski, Kerryn Husk</text>
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              <text>There has been a rapid increase in the delivery of social prescribing globally in recent years. However, a lack of theoretical framework, the diversity of social prescribing interventions and outcome measures, a lack of ongoing resources to provide services equitably and a lack of coordinated research agenda make it challenging for practitioners to know how best to put social prescribing into practice. This paper summarises perspectives from 29 UK and Australian authors and sets a course for future social prescribing implementation in four key areas: theory, measurement, resourcing and equity, and discovery (big questions on the research agenda). Eight recommendations are made: (1) multilevel or systems theory frameworks should inform programme design and implementation; (2) methods should be developed in collaboration with participants and service providers; (3) a core set of outcome measures should be developed and complemented by framework-specific measures; (4) factors at multiple levels should be included to ensure a comprehensive understanding of the experience and value of social prescribing; (5) funding models should ensure that community sector organisations providing the programmes and services are well supported; (6) social prescribing stakeholders could advocate for equitable funding through dialogue and knowledge translation; (7) future research could focus on understanding barriers and enablers of engagement in social prescribing in marginalised populations; and (8) future research should focus on link workers’ and community workers’ experiences of social prescribing. Emphasising health equity and asset-based community development, our perspective positions social prescribing not merely as a response to individual health needs but as a catalyst for a broader societal transformation.</text>
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                <text>Australian and UK Perspectives on Social Prescribing Implementation Research: theory, measurement, resourcing and discovery to ensure health equity</text>
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